Effect of Multi-Strain Probiotics on Levels of IL-6 in Saliva, and the Gingival Health Condition in 10 Years Old Children
DOI:
https://doi.org/10.32828/52d4nk13Keywords:
probiotics, cytokines, IL-6, gingivitisAbstract
- Aim of the study : to evaluate the effect of probiotic on oral health and levels of IL-6 in saliva . measuring levels of IL-6 in different intervals with measuring the gingival index for children . Material and method : A prospective study was conducted from November 18, 2023, to December 18, 2023, involving 100 children (49 females and 51 males) aged 10 years in Anbar, Iraq. Saliva samples were collected at baseline (0 days) Day 14, and Day 28 after taking probiotic lozenges to measure cytokine levels ( IL-6) using ELISA assays. Gingival health was assessed using the Gingival Index .Results: The period at 28 days for Gingival Index (GI) recorded the highest mean±SD, achieving 0.5172 ±0.23982, closely followed by the baseline period (Zero) with a mean±SD of 1.5138 ±0.18660. In contrast, the period at 14 days showed the lowest mean±SD, at 0.9446 ±0.26861. Statistical analysis indicated a significant difference among these periods (p-value < 0.05). The results for IL-6 indicate that the 14-day group exhibited the highest mean±SD, at 0.556±0.151. This was followed by the 28-day group, which showed a mean±SD of 0.523±0.113. In contrast, the baseline group (0 zero) had the lowest mean±SD, at 0.482±0.121. Descriptive statistics for the IL-6 levels in the follow-up study group . Conclusion :there is a significant decrease of gingival index after daily intake of probiotics Conclusion: The study demonstrated significant improvements in gingival health with probiotic lozenge use over 28 days. There was a marked reduction in the Gingival Index, indicating decreased gingivitis severity. IL-6 levels peaked at Day 14 and then decreased slightly by Day 28 this IL-6 levels peaked at 14 days, suggesting an initial immune response, and then slightly decreased by 28 days, reflecting an adaptation to probiotic treatment.
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