Anti-Oxidant Efficacy of Ginger Containing Dentifrice in the Control of Biofilm Induced Gingivitis. ( Randomized Parallel Clinical Trial )


  • Zainab Al-Alawi college of dentistry, Baghdad University, Baghdad, Iraq
  • Maha Abdul Aziz Ahmed college of Dentistry, Baghdad university



Dental plaque, Ginger, Gingivitis, Dentifrices, Antioxidant


Background: Gingivitis induced by biofilm is one of the most prevalent periodontal diseases. Due to their antimicrobial, anti-inflammatory, antioxidant, and other multipotent effects, a number of traditional medicinal plants are revered as pharmaceutical alternatives.

 Aim: The aim of the current study was to assess the antioxidant efficacy of ginger containing dentifrice in control patients with biofilm induced gingivitis.

Materials and methods: In a double-blind, randomized, parallel clinical trial, one hundred adults suffering from gingivitis caused by dental biofilm were split into two groups and given either a ginger-containing or a control dentifrice to use for three months. Clinically, periodontal assessment and saliva collection were performed at the baseline visit and after three months of toothpaste use in order to determine the superoxide dismutase level.

Results: Ginger containing dentifrices showed a significantly improved in plaque (0.216+0.069) and bleeding on probing (7.818+7.339) index scores. In addition, a significant increase (22.082+1.510) in the level of SOD antioxidant after 3months compared with control dentifrice. Conclusion: Compared to conventional dentifrices, herbal dentifrices demonstrated promising outcomes.


Abdulbaqi HR, Wa Ha, No Ad. “Evaluation of Salvadora Persica L. and Green Tea Anti-Plaque Effect: A Randomized Controlled Crossover Clinical Trial.” BMC Complementary and Alternative Medicine. 2016;16 (1): 1–7.

Akram Zi, Sa Sha, S Aa, A Fa. “Clinical Efficacy of Probiotics in the Treatment of Gingivitis: A Systematic Review and Meta‐analysis.” Australian Dental Journal. 2020;65 (1): 12–20.

Becerik Se, Ve Öz, Ha At, Gü At. “Gingival Crevicular Fluid and Plasma Acute‐phase Cytokine Levels in Different Periodontal Diseases.” Journal of Periodontology. 2012;83 (10): 1304–13.

Carnuta Mi, Ma De, Te Ba, La To, Mi Ra, An Vo. “Zingiber Officinale Extract Administration Diminishes Steroyl-CoA Desaturase Gene Expression and Activity in Hyperlipidemic Hamster Liver by Reducing the Oxidative and Endoplasmic Reticulum Stress.” Phytomedicine. 2018;48: 62–69.

Chuan, Ch Le, Ja Pe. “Sample Size Estimation Using Krejcie and Morgan and Cohen Statistical Power Analysis: A Comparison.” Jurnal Penyelidikan IPBL 7.2006; (1): 78–86.

Deshpande, An, Ne De, Ra Ra, Ki Pa, Vi Ja. “Effect of Green Tea, Ginger plus Green Tea, and Chlorhexidine Mouthwash on Plaque-Induced Gingivitis: A Randomized Clinical Trial.” Journal of Indian Society of Periodontology.2021; 25 (4): 307.

Disyam L. “A Comparison of Three Methods of Toothbrushing: Roll, Modified Bass and Scrub Technique.” The Journal of the Dental Association of Thailand. 1987;37 (1): 1–10.

Dugasani Sw, Ma Ra, Vi De, Ma Ka, Sa Ta, Ja Na. “Comparative Antioxidant and Anti-Inflammatory Effects of [6]-Gingerol,[8]-Gingerol,[10]-Gingerol and [6]-Shogaol.” Journal of Ethnopharmacology.2010; 127 (2): 515–20.

Faria Ti , Vi Fe, Cr Ma, An Ap, Th An Sa, Ca Ca. “Anti-Inflammatory and Antimicrobial Effects of Zingiber Officinale Mouthwash on Patients with Fixed Orthodontic Appliances.” American Journal of Orthodontics and Dentofacial Orthopedics. 2021;159 (1): 21–29.

Hassan Le Zu, Ma Ab “Evaluation the Effects of Dentifrice Containing Propolis Extract in the Control of Plaque and Gingivitis with Measuring Il-1β and Il-6 Salivary Cytokines Levels , ( Clinical and Immunological Trial ),”2020; 6–11.

Hefti Ar, Ph Mp. “Examiner Alignment and Assessment in Clinical Periodontal Research.” Periodontology 2000.2012;59 (1): 41–60.

Janakiram Ch, Br Dy. “A Public Health Approach for Prevention of Periodontal Disease.” Periodontology 2000.2020;84 (1): 202–14.

Kang Qi, Ch Ya. “Oxidative Stress and Diabetic Retinopathy: Molecular Mechanisms, Pathogenetic Role and Therapeutic Implications.” Redox Biology. 2020;37: 101799.

Kraivaphan Pe, Ch Am. “Comparative Clinical Efficacy of Three Toothpastes in the Control of Supragingival Calculus Formation.” European Journal of Dentistry. 2017; 11 (01): 94–98.

Löe Ha, Jo Si. “Periodontal Disease in Pregnancy I. Prevalence and Severity.” Acta Odontologica Scandinavica.1963; 21 (6): 533–51.

Mahyari Sa, Be Ma, Se Ah, Bi, Ma Ni, Se Pa. “Evaluation of the Efficacy of a Polyherbal Mouthwash Containing Zingiber Officinale, Rosmarinus Officinalis and Calendula Officinalis Extracts in Patients with Gingivitis: A Randomized Double-Blind Placebo-Controlled Trial.” Complementary Therapies in Clinical Practice. 2016;22: 93–98.

Murakami Sh, Bri Me, An Ma, Ia Cha. “Dental Plaque–Induced Gingival Conditions.” Journal of Clinical Periodontology 2018;.45: S17–27.

Najah Ay, Su Sa, Ha Ak, Ma Ah, Lu Ab. “Measurement of Serum Superoxide Dismutase Levels in Women with Polycystic Ovarian Syndrome and Chronic Periodontitis.” Journal of Baghdad College of Dentistry. 2017; 29 (4): 76–81.

Newman Mi, He Ta, Pe RK, Fe AC. Newman and Carranza’s Clinical Periodontology E-Book. Elsevier Health Sciences. 2018.p:4.

Organization, World Health. Oral Health Surveys: Basic Methods. World Health Organization. 2013.p:2.

Roi Al, La CR, Ci IR, Ru EL, Si Bo, Ro IM. “A New Approach for the Diagnosis of Systemic and Oral Diseases Based on Salivary Biomolecules.” Disease Markers. 2019;2(7):22.

Sana MA, Ma AA. “Antibacterial Effect of Aqueous and Alcoholic Ginger Extracts on Periodontal Pathogen Aggregatibacter Actinomycetem Comitans [An in Vitro Study](Part 1).” Tikrit Journal for Dental Sciences.2017; 5 (1): 1–10.

Santos Br, Su. “Ginger: Panacea or Consumer’s Hype?” Applied Sciences.2019;9 (8): 1570.

Syndergaard Be, Mo Al‐Sa, Ri JK, Ji Xi, Cr SM. “Salivary Biomarkers Associated with Gingivitis and Response to Therapy.” Journal of Periodontology. 2014;85 (8): e295–303.

Thomas Bi, Am Ra, Ba Ra Pr, Su Ku. “Serum Levels of Antioxidants and Superoxide Dismutase in Periodontitis Patients with Diabetes Type 2.” Journal of Indian Society of Periodontology. 2014;18 (4): 451.

Turesky Sa. “Reduced Plaque Formation by the Chloromethyl Analogue of Victamine C.” J Periodontol. 1970; 41: 41–43.

Yang J, W Z, L Du, H Wu, J Gu. “Comparative Antioxidant Properties of Some Gingerols and Shogaols, and the Relationship of Their Contents with the Antioxidant Potencies of Fresh and Dried Ginger (Zingiber Officinale Roscoe).” 2018;2(5):8.

Zare Ja, Ah Ha, Ha Gh, Me Ra, Ho Ra, Parvin Salehi, and Mohammad Hosein Haghighi-Zadeh. “The Effects of Ginger Supplementation on Inflammatory, Antioxidant, and Periodontal Parameters in Type 2 Diabetes Mellitus Patients with Chronic Periodontitis under Non-Surgical Periodontal Therapy. A Double-Blind, Placebo-Controlled Trial.” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy.2019;1(2): 1751–61.

Zhu Ni, Xa Ch, Pe Pa, Li Ge, Ma Qi, Yu Wa. “Silver-Doped Bioactive Glass/Chitosan Hydrogel with Potential Application in Dental Pulp Repair.” ACS Biomaterials Science & Engineering.2019; 5 (9): 4624–33.




How to Cite

Al-Alawi, Z., & Abdul Aziz Ahmed , M. (2023). Anti-Oxidant Efficacy of Ginger Containing Dentifrice in the Control of Biofilm Induced Gingivitis. ( Randomized Parallel Clinical Trial ). Mustansiria Dental Journal, 19(2), 241–250.

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