Topical Nigella Sativa in the treatment of oro-genital ulceration in Behcet's disease.

Abstract

To assess the effect of Nigella sativa oil as a topical preparation for treatment of oro- genital ulceration of Behcet's disease. This is a double blinded therapeutic trial in which 40 patients with Behcet's disease manifested as recurrent episodes of oral and genital ulceration were enrolled into 2 groups; Nigella sativa oil was applied as 10% in glycerin topically 3 times / daily to the first 20 patients. The other 20 were given glycerin only. Assessment was done 4 days then 8 days after treatment.
Results were recorded as they appeared in clinical examination and those records were arranged in tables for both groups concerning oral and genital ulceration cases.
Nigella sativa oil is a new topical agent for promotion of healing of oro- genital ulceration of Behcet’s disease which may act through Pits anti-inflammatory effect