The effect of fluoride on osteoblast cell population after in vivo administration

Abstract

Background: The osteoblast is characterized by its ability to synthesize a well
defined mineralized collagenous matrix, regulate the remodeling process by
synthesizing local hormone, specific molecules and alkaline phosphatase
enzyme .The aim of this study was to evaluate the effect of Sodium Fluoride
administration in vivo on osteoblast cell.
Materials and methods: Fourteen pregnant Sprague- Dawley rats were used, 8 of
them received 100ppm Fluoride, others did not received and considered as
controls. Bone biopsies from neonatal rat were studied histologically and
histochemically.
Results: Active proliferation of osteoblast and their progenitor cells with active
localization of alkaline phosphatase in neonatal jaw bone treated with Sodium
Fluoride.
Conclusion: under the condition of the present study, the Sodium Fluoride can be
used successfully to enhance bone formation.