Immunohistochemical detection of the expression of the cell adhesion molecules ICAM-1 & VCAM-1 in Pyogenic granuloma

Abstract

Pyogenic granuloma is a relatively common benign vascular lesion of the oral
mucosa & skin whose exact cause is unknown. The study of the expression of cell
adhesion molecules (ICAM-1 & VCAM-1) in oral pyogenic granuloma was
performed.
Fifteen formalin- fixed, paraffin-embedded oral pyogenic granuloma were studied
using LSAB/HRP immunohistochemical technique.
Mild to moderate expressions of cell adhesion molecules was demonstrated among
different cell types of pyogenic granuloma suggesting that inflammatory response of
gingival tissue against oral antigens (gram negative bacteria) may play a major role in
inflammatory neovasculairization & hence pathogenesis of pyogenic granuloma .