Characteristic Intensity And pattern Of Staining Of P53 And Ki67 In Oral Squamous Cell Carcinoma

Abstract

To investigate the characteristic intensity and pattern of staining of P53 and Ki67
in oral squamous cell carcinoma in different grading of lesions.
Thirty patients with oral squamous cell carcinoma were collected and used to
detect the intensity and pattern of staining of P53 and ki67 markers by
immunohistochemical method.
Immunoreactivity of this study for P53 found that 21 (70%) were positive in
different grading of disease. Most frequent combination includes strong intensity in
11 cases (52%) and diffuse pattern in 15 cases (71%).
Immunoreactivity of Ki67 in oral squamous cell carcinoma indifferent grading
was found positivity for ki67 in 25 cases (83%) and the most frequent pattern of
staining was the scattered which seen in 20 cases (80%) and 5 cases (20%) had diffuse
pattern of staining.
In conclusion the study revealed that the intensity and pattern of staining of P53
and Ki67 correlate with well differentiated oral squamous cell carcinoma.