Radiographic evaluation of the S2-complex drug on the alveolar bone height

Abstract

The S2-complex drug is a chemical preparation of a low molecular weight
synthetic organometalic complex, and it has experimented in many researches to prove
it’s activity in the treatment of the cancerous tumors, without any side effects. This drug
is a potent immunomodulat or that stimulates both, the humoral a.nd cell mediated
,immune responses
To examine the effect of S2—complex administered locally and was designed to
test the potential effectiveness of S2-complex in the management of periodontal disease
.associated bone loss by radiographic evaluation
Thirty six pairs of similarly involved periodontal pockets in (20) patients aged
between (30-50) years old with pocket depth more than 6 mm were selected. Split mouth
,randomized study was carried out. Scaling and root planing was carried out in both sides
in test side received S2- complex for five days in a daily dose of O.l mm/kg injected
deeply until reaching the bone of affected site, while the control side was received distal
water for 5 days in a daily dose of 0.l mm/kg injected in the same way as that for test
side. S2 complex was infiltrated locally through the gingival tissue of the effected site
.deeply until reach the defect bone using disposable insulin syringes
Clinical attachment level of gingiva were recorded at baseline and repeated
once every 2 weeks. Periapical radiographs were taken for both test and control sides at
baseline and at the termination of the treatment after 2 months. A long the time of study
,the patients put on a program of motivation to keep a good stander of oral hygiene
Clinical and radiographical parameters in general showed improvement with both test
.and control groups, with a statical significant difference between them
Radiographical evaluation showed high differences in hight and density of bone for
both groups, and effect to S2-complex was on sites of anterior and molar areas according